Manipulation of Intestinal Microbiome Composition Affects Liver Regeneration after 70% Hepatectomy in a Murine Model

Background: Previous studies demonstrated the effects of Intestinal microbiota composition on physiologic and pathologic processes in liver. Our aim was to study effect intestinal process liver regeneration (LR) using a model fecal transplantation (FMT) prior partial hepatectomy (PH). Methods: We used 70% PH mice induce LR. LR assessed mouse weight ratio, KI67 staining, RT-PCR for Cyclin D1. microbiome manipulated by aggressive antibiotic treatment followed FMT. Normal, as well obese received FMT gavage from normal mice, vehicle saline. Results: not affected treatment. healthy compared resulted improved (Fig. 1 A), that associated with decreased increased postoperative mortality (45% vs. 8%). Obese receiving had B). Conclusions: is composition, can be Whereas transfer donor enhances LR, dysbiotic HFD impairs following PH.